09/13/2019 (Friday)
07:00 am – 07:30 am | Registration
07:30 am – 07:40 am | Opening and Welcome
Rui Manuel Reis, PhD (Barretos Cancer Hospital, Barretos, Brazil) Executive Scientific Director
07:40 am – 09:40 am | Session 1
Hereditary Cancer and genetic risk factors
Discussion Leaders: Rui Manuel Reis, PhD
07:40 am – 08:10 am | Genetic susceptibility and treatment response in patients with triple negative breast cancer
Speaker: Dirce Maria Carraro,PhD Dirce Maria Carraro, PhD (AC Camargo Cancer Center, São Paulo, Brazil)
08:10 am – 08:40 am | Deciphering genetic susceptibility to lung cancer
Speaker: James McKay, PhD ( IARC, Lyon, France)
08:40 am – 09:10 am | The germline mutation landscape of Hereditary Breast Cancer in Brazil
Speaker: Edenir Inez Palmero, PhD (Barretos Cancer Hospital, Barretos, Brazil)
09:10 am – 09:40 am | Discussion
09:40 am – 10:10 am | Coffee-break
10:10 am – 12:10 am | Session 2
Molecular biomarkers in translational oncology
Discussion Leaders: Patricia Reis, PhD / Márcia Maria C. Silveira, PhD
10:10 pm – 10:40 am | Clonal hematopoiesis and malignant clonal evolution
Speaker: Rodrigo Calado, MD, PhD ( (FMRP/USP, Ribeirão Preto, Brazil)
10:40 am – 11:10 am | Alterations of DNA methylation as biomarkers in tumors from the upper aerodigestive tract
Speaker: Sheila Coelho Soares Lima, PhD (National Cancer Institute – INCA, Rio de Janeiro, Brazil)
11:10 am – 11:40 am | The Molecular Landscape of Brazilian Lung Cancer: Searching for Clinically Relevant Biomarkers
Speaker: Letícia Ferro Leal, PhD (Barretos Cancer Hospital, Barretos, Brazil)
11:40 am – 12:10 am | Discussio
12:10 am – 12:40 pm | Combining Genomics and Radiomics for improved Cancer management
Speaker: Ana Paula Korbes
12:40 am – 01:40 am | Lunch
01:40 am – 03:40 am | Session 3
Environmental factors and Exposome in cancer development
Discussion Leaders: Henrique Silveira, PhD / Fabiana de Lima Vazquez, PhD
01:40 pm – 02:10 pm | Etiological factors influence differences and consequences in lipid bodies formation between obese and non-obese associated esophageal tumors
Speaker: Luis Felipe Ribeiro Pinto, PhD (National Cancer Institute – INCA, Rio de Janeiro, Brazil)
02:10 pm – 02:40 pm | Exploring interactions between the exposome and cancer through metabolomics – Application to cohort studies
Speaker: Augustin Scalbert, PhD (International Agency for Research on Cancer - IARC, Lyon, France)
02:40 pm – 03:10 pm | Long term exposure assessment to urban air pollution: an autopsy based study
Speaker: Paulo Hilário Nascimento Saldiva, MD, PhD (Universidade de São Paulo, Instituto de Estudos Avançados USP, São Paulo, Brazil)
03:10 pm – 03:40 pm | Discussion
03:40 am – 05:10 am | Session 4
Early detection and cancer screening
Discussion Leaders: Denise Peixoto Guimarães, MD, PhD / Ricardo dos Reis, MD
03:40 am – 04:10 am | What tools do we have to eliminate cervical cancer?
Speaker: Luisa Lina Villa, PhD ( Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil)
04:10 am – 04:40 pm | Translational research in cancer screening at Barretos Cancer Hospital
Speaker: Ana Carolina de Carvalho, PhD (Barretos Cancer Hospital, Barretos, Brazil)
04:40 pm – 05:10 pm | Discussion
05:10 pm – 05:55 pm | Oral presentation of Best Abstracts
Discussion Leader: Jeremy Andrew Squire, PhD / Flavia Gonçalves Fernandes
05:10 pm – 05:20 pm | Expression of GNAS, TP53, and PTEN Improve the Prognostication of SHH Medulloblastoma
Speaker – Luciane Sussuchi da Silva (Barretos Cancer Hospital, Barretos, Brazil)
05:20 pm – 05:30 pm | Circulating tumor DNA (ctDNA) predicts early recurrence in advanced melanoma patients
Speaker – Gabriella Taques Marczynski (Barretos Cancer Hospital, Barretos, Brazil)
05:30 pm – 05:40 pm | Immune Profile Indicates That Down-Modulation Of Innate And Adaptative Immune Cells Are Associated With Metastatic Progression In Rectal Cancer
Speaker – Iael Weissberg (Sao Paulo State University - UNESP, Botucatu, Brazil)
05:40 pm – 05:55 pm | Discussion
05:55 pm – 07:55 pm – Cocktail and visit to the posters.
09/14/2019 (Saturday)
07:30 am – 09:30 am – Session 5
Personalized Medicine
Discussion Leaders: Luís Eduardo Rosa Zucca, MD / Jeremy Andrew Squire, PhD
07:30 am – 08:00 am – Raf Kinase Inhibitory Protein (RKIP): a new predictor of EGFR targeted therapy response in solid tumors?
Speaker: Olga Martinho, PhD (University of Minho, Portugal)
08:00 am – 08:30 am – The Brazilian Initiative on Precision Medicine (BIPMed): contributions of the past four years
Speaker: Iscia Lopes Centes, PhD ( UNICAMP, Campinas, Brazil)
08:30 am – 09:00 am – GBM: a fatal tumor and its perpetual stem cells
Speaker: Vivaldo Moura Neto, PhD (Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil)
09:00 am – 09:30 am – Discussion
09:30 am – 10:00 am – Coffee-break
10:00 am – 11:30 pm – Session 6
Innovative approaches for cancer discovery and treatment
Discussion Leaders: Osvaldo Novais de Oliveira Jr, PhD / Matias Eliseo Melendez, PhD
10:00 am – 10:30 am – The use of multi-omic data integration to reveal potential targets in HPV-related cancers
Speaker: Marcelo Alves Soares, PhD (National Cancer Institute – INCA, Rio de Janeiro, Brazil)
10:30 am – 11:00 am – Mechanism of action of combi-molecules rationally designed to block multiple adverse signalling pathways and reverse MGMT-mediated resistance: relevance to immuno-oncology
Speaker: Bertrand Jean Claude, PhD (University McGill, Montreal, Canada)
11:00 am – 11:30 pm – Discussion
11:30 pm – 12:00 pm – Analysis of immune checkpoints with IHC: the importance of validation in the right application and the establishment of multiplexed IHC assays
Speaker: Jonah Riddell, PhD - Cell Signaling Technology
12:00 pm – 01:30 pm – Lunch and visit to the posters
01:30 pm – 03:30 pm – Session 7
Immunotherapy and tumor microenvironment
Discussion Leaders: Céline Marques Pinheiro, PhD / Flávio Cárcano, MD, PhD
01:30 pm – 02:00 pm – Lactate and acidification represent metabolic checkpoints in the tumor environment
Speaker: Marina Kreutz, PhD ( University Hospital Regensburg, Regensburg, Alemanha)
02:00 pm – 02:30 pm – Systemic and tissue immune networks to identify novel targets and therapy response markers in cancer
Speaker: Kenneth Gollob, PhD (AC Camargo Cancer Center, São Paulo, Brazil)
02:30 pm – 03:00 pm – Cross talk between STAT3 and NFkB underlies immune evasion mechanisms in cervical cancer
Speaker: Ana Paula Lepique,PhD (University of São Paulo – São Paulo, Brazil)
03:00 pm – 03:30 pm – Discussion
03:30 pm – 05:30 pm – Session 8
Experimental models in translational oncology
Discussion Leaders: Carlos Alberto Scrideli, MD, PhD / Silvia Aparecida Teixeira, PhD
03:30 pm –04:00 pm – Zika virus: from enemy to ally
Speaker: Mayana Zatz, PhD (University of São Paulo – São Paulo, Brazil)
04:00 pm – 04:30 pm – Exploiting viruses for the treatment of brain tumors
Speaker: Sean Edward Lawler, PhD (Brigham and Women's Hospital – Harvard Medical School - Boston, USA)
04:30 pm – 05:00 pm – Immune cell therapies for cancer: future promises and challenges
Speaker: Nandhu Mohan Sobhana, PhD (Takeda Pharmaceutical International Co, Cambridge, USA)
05:00 pm – 05:30 pm – Discussion
05:30 pm – 06:00 pm – Awards of the best oral presentation and poster
Discussion Leader:
06:00 pm – 06:15 pm – Closing remarks
